{"product_id":"suboral™-sl-hmw-cool-mint-anhydrous-water-soluble-sublingual-vehicle","title":"SubOral™ SL HMW Anhydrous Sublingual Vehicle (Cool Mint)","description":"\u003cdiv class=\"concept-product-benefits\"\u003e\n\u003cp\u003eSubOral™ SL HMW is an anhydrous sublingual vehicle formulated to improve the solubility of oil and water-soluble actives of both large and small molecular weight. It is specifically designed to offer enhanced bioavailability potential for transcellular and paracellular transport. Uniquely formulated with its water-soluble properties, SubOral™ SL HMW incorporates a dual Natural Deep Eutectic Solvent (NADES) system and Nano PEGylated Transport System™ (NPTS)¹⁰ that aids in forming and stabilizing micelles into nano emulsions to improve solubility of both hydrophobic and hydrophilic molecules for optimal solubilization and permeation enhancing properties.\u003c\/p\u003e\n\u003cp\u003eSubOral™ SL HMW is formulated with Sodium Caprylate (C8), widely known as an intestinal permeation enhancer and biological stabilizer for oral delivery of fragile therapeutic peptide-based pharmaceuticals, preventing aggregation, denaturation, and promoting the unfolding of functional proteins and peptides.  \u003c\/p\u003e\n\u003cp\u003eThis vehicle features an Oral Osmotic System (OROS) with a tonicity agent to adjust its osmotic pressure to match the isotonic conditions of human body fluids (300 mOsm\/L). Iso-osmotic conditions prevent cell damage (lysis or crenation), decrease tissue irritation for repeated use, and optimize drug absorption and bioavailability.\u003c\/p\u003e\n\u003cp\u003eAdditionally, SubOral™ SL HMW is formulated with a unique cyclodextrin oligosaccharide with a hydrophilic exterior and a hydrophobic, non-polar interior cavity that can encapsulate parts of large peptides to assist in improving its overall solubility. This strategy is common in advanced formulations and is co-administered with GLP-1 agonists (such as semaglutide) for enhanced solubility in numerous drug formulations.\u003cbr\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eAppearance:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eWhite to off-white opaque viscous liquid\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eHighlights:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv\u003e\n\u003cul\u003e\n\u003cli\u003eAnhydrous water-soluble formulation enabling extended BUDs for a wide spectrum of prescriptions\u003c\/li\u003e\n\u003cli\u003eEmploys functional ingredients for large and small molecular weight compounds to be administered sublingually\u003c\/li\u003e\n\u003cli\u003eRapidly forms an occlusive hydrogel emulsion when exposed to saliva for improved bioavailability\u003c\/li\u003e\n\u003cli\u003eWater based hydrogels vs. oil-based vehicles offer several advantages for sublingual delivery:\n\u003cul\u003e\n\u003cli\u003eSuperior bioadhesion⁸ and hydration potential for improved bioavailability via oral mucosal tissue delivery with a wide range of molecular weight actives\u003c\/li\u003e\n\u003cli\u003eSeveral oral delivery studies show water-soluble sublingual vehicles offer up to 5 times⁹ more bioavailability than oil-soluble formulations\u003c\/li\u003e\n\u003cli\u003eWater-soluble properties allow for precise, uniform dosing without separation issues common in oil-based emulsions\u003c\/li\u003e\n\u003cli\u003eAbility to target a precise pH to maintain stability and solubility\u003c\/li\u003e\n\u003cli\u003eTaste, texture, and palatability are widely accepted\u003c\/li\u003e\n\u003cli\u003eGenerally hypoallergenic and less likely to cause irritation than some oil sources\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e Formulated with a unique dual NADES and NPTS system that assists with solubilization and enhances penetration, leading to improved bioavailability\u003c\/li\u003e\n\u003cli\u003ePromotes the unfolding of functional proteins and peptides, preventing aggregation more effectively than other systems for improved bioavailability\u003c\/li\u003e\n\u003cli\u003eCan be easily formulated with Salcaprozate Sodium (SNAC) due to its water-soluble properties\u003c\/li\u003e\n\u003cli\u003eFormulated to improve the solubility of poorly soluble drugs\u003c\/li\u003e\n\u003cli\u003eIdeally formulated for both HMW therapeutic biomolecules (peptides\/proteins) as well as small molecular drugs (APIs)\u003c\/li\u003e\n\u003cli\u003eCan be homogenized without base degradation\u003c\/li\u003e\n\u003cli\u003eIdeal pH that mimics the natural oral mucosa pH\u003c\/li\u003e\n\u003cli\u003eIncorporates an Oral Osmotic System (OROS) with a widely used tonicity agent\u003c\/li\u003e\n\u003cli\u003eStable suspension properties formed through a unique microgel network\u003c\/li\u003e\n\u003cli\u003eImproved protein stabilizing properties\u003c\/li\u003e\n\u003cli\u003eSugar-free; utilizes only natural sweeteners\u003c\/li\u003e\n\u003cli\u003eFor oil and water-soluble small and large molecules\u003c\/li\u003e\n\u003cli\u003eOcclusive bio-adhesive properties for prolonged absorption advantages\u003c\/li\u003e\n\u003cli\u003eExcellent suspension properties to improve drug loading capacity and increase the overall bioavailability of the medication\u003c\/li\u003e\n\u003cli\u003eDemonstrated great taste for prolonged sublingual absorption leading to improved patient compliance and satisfaction\u003c\/li\u003e\n\u003cli\u003eAllergen-free\/gluten-free\u003c\/li\u003e\n\u003cli\u003eWater and oil miscible flavor ready\u003c\/li\u003e\n\u003cli\u003eIncorporates our proprietary Bitter-Bloc™ Technology for optimal palatability\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eNatural Deep Eutectic Solvents (NADES) and Therapeutic Deep Eutectic Systems (THEDES):\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003eSeveral studies¹²³⁴ have demonstrated that certain hydrated Deep Eutectic Solvents (DESs) can interact with intercellular lipids, creating wider water channels between lipid vesicles, enhancing the paracellular-like transport of hydrophilic compounds. This can be very effective through oral mucosa, a highly vascularized thin membrane. DESs and their specialized derivatives, Therapeutic Deep Eutectic Systems (THEDES), effectively increase the permeability of biological barriers⁵ (such as the skin, intestinal wall) to various agents, including drugs, proteins, and nanoparticles. Their function leads to higher solubility and superior penetration through biological tissues. DESs enhance the systemic absorption⁶ of subcutaneously injected therapeutic proteins (such as insulin) or larger proteins\/peptides by reducing interactions with the subcutaneous matrix, a mechanism that can involve modulating the transport pathways. In essence, the unique properties of a DES can be leveraged in drug delivery systems to open or widen the paracellular route temporarily and reversibly⁷, allowing for improved absorption of drugs that would otherwise struggle to cross epithelial barriers.\u003c\/p\u003e\n\u003cp\u003e¹National Library of Medicine, Penetration Process of a Hydrated Deep Eutectic Solvent Through the Stratum Corneum and its Application as a Protein Penetration Enhancer. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7493194\/\u003c\/p\u003e\n\u003cp\u003e²MDPI Journal, Advancements in Therapeutic Deep Eutectic Solvents as Multifunctional Transdermal Delivery Systems. https:\/\/www.mdpi.com\/1999-4923\/18\/3\/360\u003c\/p\u003e\n\u003cp\u003e³International Journal of Pharmaceutical Sciences, Deep Eutectic Solvents as Solubility Enhancers: A Systematic Review. Volume 03 | Issue 10 | Article Id IJPS\/250310415\u003c\/p\u003e\n\u003cp\u003e⁴International Journal of Pharmaceutical Sciences, Development and In Vitro Evaluation of a Deep Eutectic System to Improve Cefuroxime Axetil Solubility by Enhancing the Dissolution. Volume 03 | Issue 12 | Article Id IJPS\/250312253\u003c\/p\u003e\n\u003cp\u003e⁵MDPI Journal, Deep Eutectic Systems as Novel Vehicles for Assisting Drug Transdermal Delivery. https:\/\/www.mdpi.com\/1999-4923\/14\/11\/2265\u003c\/p\u003e\n\u003cp\u003e⁶Wiley Advanced Science, Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics. https:\/\/advanced.onlinelibrary.wiley.com\/doi\/10.1002\/advs.202205389\u003c\/p\u003e\n\u003cp\u003e⁷ScienceDirect, Deep eutectic solvents@enteric technology for orally delivering anticoagulant macromolecule drug. https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211383525007178?via%3Dihub\u003c\/p\u003e\n\u003cp\u003e⁸ScienceDirect, Mucoadhesion, hydration and rheological properties of non-aqueous delivery systems (NADS) for the oral cavity. https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0300571208000274?via%3Dihub\u003c\/p\u003e\n\u003cp\u003e⁹True North Labs, April 24, 2024, Water-soluble or Oil-Soluble Cannabinoids: Exploring mechanisms of absorption, bioavailability, and fat solubility of cannabis products. https:\/\/www.truenorthlabs.ch\/news\/water-soluble-vs-oil-soluble-cannabis-products-key-differences-and-why-they-matter#:~:text=Water%2Dsoluble%20powder%20has%20been,with%20a%20high%2Dfat%20meal\u003c\/p\u003e\n\u003cp\u003e¹⁰National Library of Medicine \/ International Journal of Nanomedicine. 2007 Dec;2(4):735–741. PEGylation of nanoparticles improves their cytoplasmic transport.  https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2676827\/\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003c\/div\u003e\n\u003cp\u003e\u003cspan style=\"text-decoration: underline;\"\u003e\u003cstrong\u003eAdditional Information:\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMSDS: \u003c\/strong\u003eAvailable upon request\u003cbr\u003e\u003cstrong\u003eTechnical Data Sheet:\u003c\/strong\u003e See resources\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eInquire for bulk pricing\u003c\/em\u003e\u003c\/p\u003e\n\u003c\/div\u003e","brand":"SpecializedRx","offers":[{"title":"500 mL","offer_id":51284952351015,"sku":"B0257-80","price":195.0,"currency_code":"USD","in_stock":false},{"title":"4 L","offer_id":51284952383783,"sku":"B0257-85","price":1300.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0272\/1392\/2413\/files\/B0257_109748a0-7c7f-47c1-a037-51028e6bbbbc.jpg?v=1786390981","url":"https:\/\/specializedrx.com\/products\/suboral%e2%84%a2-sl-hmw-cool-mint-anhydrous-water-soluble-sublingual-vehicle","provider":"SpecializedRx","version":"1.0","type":"link"}